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Question 208:



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 The usual warning with 1-sided hypothesis testing is that you should decide ahead of data-collection if you will use a two-sided or one-sided. The other warning is that you should be rather certain that the treatment won't in fact increase the incidence of the disease.

You've stated that the new quality-of-care project is expected to reduce the proportion of a disease, assuming you are still in the planning stages, this seems like an acceptable use.  Of course, once you do collect the data, you can always also perform the more conservative 2-sided test and also see if those results are significant.

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